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VOLUME 14 , ISSUE 1 ( January-March, 2024 ) > List of Articles


Comparison of In-office Bleaching Agent Application Times on Tooth Sensitivity and Color Change: A Systematic Review and Meta-analysis

Yasmeen M Azeem, Kiranmayi Govula, Lavanya Anumula, Harika Paluru, Chandrasekhar Soudagiri

Keywords : Bleaching times, Color change, Hydrogen peroxide, In-office tooth bleaching, Tooth sensitivity

Citation Information : Azeem YM, Govula K, Anumula L, Paluru H, Soudagiri C. Comparison of In-office Bleaching Agent Application Times on Tooth Sensitivity and Color Change: A Systematic Review and Meta-analysis. Int J Prosthodont Restor Dent 2024; 14 (1):50-57.

DOI: 10.5005/jp-journals-10019-1439

License: CC BY-NC 4.0

Published Online: 30-03-2024

Copyright Statement:  Copyright © 2024; The Author(s).


Purpose: To compare the effect of in-office bleaching agent application times on tooth sensitivity and degree of color change. Materials and methods: PubMed, Web of Science, EBSCO, Scopus, Cochrane Library, DOAJ, LILAC, gray literature, and manual search. Randomized clinical trials or clinical studies that recruited patients aged 18 years or above for in-office tooth bleaching were included. The focused question was, “Do application times of in-office bleaching agents affect tooth sensitivity and degree of color change”? The risk of bias (RoBs) and meta-analysis were analyzed using review-manager software. Results: The database search identified 159 citations and 13 citations through manual search. After removing duplicates, the abstracts of 93 studies were assessed. Around 10 full-text articles were studied, and finally, four articles were included for qualitative analysis. The RoBs in the four included studies was considered to be low. Conclusion: Systematic review and meta-analyses showed that single prolonged bleaching has significantly reduced postbleaching tooth sensitivity compared to the multiple application times of the bleaching agent. The color change seemed the same with both application times of the bleaching agent.

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