Rehabilitation of an amputated toe using high temperature vulcanizing (HTV) silicone prosthesis aiming toward comfort and esthetics for a patient whose right toe was missing. Amputation is the removal of all or part of a limb. It can result from medical, surgical, congenital, or psychiatric reasons. Rehabilitating patients with amputated toe not only restores the function but also satisfies their esthetic needs, self-confidence and helping them to cope with the difficulties of amputation. The patient reported to the Department of Prosthodontics with the chief complaint of missing teeth and wants to get it replaced, and it was noticed that his right toe was amputated 2 years back due to diabetic foot ulcer. This case report describes the prosthodontic management of the patient with amputated right toe due to diabetic foot ulcer. Rehabilitating patients with amputated toe not only resulted in improved social interaction, function, and comfort of the patient, it also contributed to the physical and mental well-being of the individual in improving the quality of life of the patient.